|
Chronic eosinophilic leukemia
|
0.400 |
FusionGene
|
disease |
ORPHANET |
Identification of JAK2 as a mediator of FIP1L1-PDGFRA-induced eosinophil growth and function in CEL.
|
22523564 |
2012 |
|
Chronic eosinophilic leukemia
|
0.400 |
FusionGene
|
disease |
ORPHANET |
Thus, imatinib may be very effective for treating the early cardiac involvement of FIP1L1-PDGFRA-positive CEL, but it needs to be used cautiously.
|
17988989 |
2007 |
|
Chronic eosinophilic leukemia
|
0.400 |
FusionGene
|
disease |
ORPHANET |
FIP1L1-PDGFRA-Positive Chronic Eosinophilic Leukemia: A Low-Burden Disease with Dramatic Response to Imatinib - A Report of 5 Cases from South India.
|
24764730 |
2014 |
|
Chronic eosinophilic leukemia
|
0.400 |
FusionGene
|
disease |
ORPHANET |
We recently identified the FIP1L1-PDGFRA fusion gene in approx 50% of HES/CEL cases.
|
16502585 |
2006 |
|
Burkitt Lymphoma
|
0.300 |
FusionGene
|
disease |
ORPHANET |
PDGFRA rearrangement leading to hyper-eosinophilia, T-lymphoblastic lymphoma, myeloproliferative neoplasm and precursor B-cell acute lymphoblastic leukemia.
|
21304535 |
2011 |
|
Burkitt Lymphoma
|
0.300 |
FusionGene
|
disease |
ORPHANET |
Therapy-related acute myeloid leukemia with eosinophilia, basophilia, t(4;14)(q12;q24) and PDGFRA rearrangement: a case report and review of the literature.
|
26191303 |
2015 |
|
Precursor B-cell lymphoblastic leukemia
|
0.300 |
FusionGene
|
disease |
ORPHANET |
Here, we report a rare case of therapy-related acute myeloid leukemia with PDGFRA rearrangement after chemotherapy for prior B lymphoblastic leukemia (B-ALL).
|
26191303 |
2015 |
|
Precursor B-cell lymphoblastic leukemia
|
0.300 |
FusionGene
|
disease |
ORPHANET |
PDGFRA rearrangement leading to hyper-eosinophilia, T-lymphoblastic lymphoma, myeloproliferative neoplasm and precursor B-cell acute lymphoblastic leukemia.
|
21304535 |
2011 |
|
Myeloid and/or lymphoid neoplasm associated with platelet derived growth factor receptor alpha rearrangement
|
0.300 |
FusionGene
|
disease |
ORPHANET |
Myeloid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, and FGFR1: a review.
|
23489324 |
2013 |
|
Gastrointestinal Stromal Tumors
|
0.800 |
CausalMutation
|
group |
CLINVAR |
A great majority of GISTs with PDGFRA mutations represent gastric tumors of low or no malignant potential.
|
15146165 |
2004 |
|
Gastrointestinal Stromal Tumors
|
0.800 |
CausalMutation
|
group |
CLINVAR |
Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate.
|
16638875 |
2006 |
|
Gastrointestinal Stromal Tumors
|
0.800 |
CausalMutation
|
group |
CLINVAR |
We determined the KIT and PDGFRA mutation status of 1,105 unique GISTs using a combination of denaturing high-performance liquid chromatography and direct sequencing.
|
15928335 |
2005 |
|
Gastrointestinal Stromal Tumors
|
0.800 |
CausalMutation
|
group |
CGI |
|
|
|
|
Gastrointestinal Stromal Tumors
|
0.800 |
CausalMutation
|
group |
CLINVAR |
We performed a cytogenetic analysis and screened for mutations of the KIT and PDGFRA kinase domains in 26 resistant GISTs.
|
15685537 |
2005 |
|
Gastrointestinal Stromal Tumors
|
0.800 |
CausalMutation
|
group |
CLINVAR |
Crenolanib inhibits the drug-resistant PDGFRA D842V mutation associated with imatinib-resistant gastrointestinal stromal tumors.
|
22745105 |
2012 |
|
Gastrointestinal Stromal Tumors
|
0.800 |
CausalMutation
|
group |
CLINVAR |
Outcome of patients with platelet-derived growth factor receptor alpha-mutated gastrointestinal stromal tumors in the tyrosine kinase inhibitor era.
|
22718859 |
2012 |
|
Gastrointestinal Stromal Tumors
|
0.800 |
CausalMutation
|
group |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
|
Gastrointestinal Stromal Tumors
|
0.800 |
CausalMutation
|
group |
CLINVAR |
Efficacy of Imatinib in Patients with Platelet-Derived Growth Factor Receptor Alpha-Mutated Gastrointestinal Stromal Tumors.
|
26130666 |
2016 |
|
Gastrointestinal Stromal Tumors
|
0.800 |
CausalMutation
|
group |
CLINVAR |
Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor.
|
14645423 |
2003 |
|
Gastrointestinal Stromal Tumors
|
0.800 |
CausalMutation
|
group |
CLINVAR |
Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity.
|
17087936 |
2006 |
|
Gastrointestinal Stromal Tumors
|
0.800 |
CausalMutation
|
group |
CLINVAR |
Activity of dasatinib, a dual SRC/ABL kinase inhibitor, and IPI-504, a heat shock protein 90 inhibitor, against gastrointestinal stromal tumor-associated PDGFRAD842V mutation.
|
18794084 |
2008 |
|
Gastrointestinal Stromal Tumors
|
0.800 |
CausalMutation
|
group |
CLINVAR |
Molecular correlates of imatinib resistance in gastrointestinal stromal tumors.
|
16954519 |
2006 |
|
Gastrointestinal Stromal Tumors
|
0.800 |
CausalMutation
|
group |
CLINVAR |
Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.
|
12949711 |
2003 |
|
Hypereosinophilic syndrome
|
0.600 |
CausalMutation
|
disease |
CGI |
|
|
|
|
melanoma
|
0.490 |
CausalMutation
|
disease |
CGI |
|
|
|